Welcome to the Sheraton Clayton Plaza Hotel St. Louis in Missouri. We’re situated in the midst of unique shopping and entertainment options, including a variety of restaurants within an eight block radius. The Clayton neighborhood is also home to several corporate headquarters including Brown Shoe Co, Enterprise Auto, Ernst & Young, and Furniture Brands International.  Great for business or leisure travel, the hotel includes updated guest rooms and boasts new and contemporary meeting spaces perfect for any event.

Newly redesigned from top to bottom, the Sheraton Clayton Plaza Hotel St. Louis infuses a contemporary look and comfortable feel into it’s guest rooms and throughout the hotel. Click Here to see our new renovations. Count on a good nights rest with the Sheraton Sweep Sleeper Bed, experience the "Mmmmm" of Alexander's Restaurant and stay connected in our communications hub - the Link @ Sheraton experienced by Microsoft. Plus, the hotel is 100% smoke-free.

Our updated and newly renovated meeting space combines modern function and warmth within 15,000 square feet of business and event space. From business meetings to wedding receptions, the Sheraton Clayton Plaza Hotel St. Louis is the perfect choice. Our meeting specialists make sure everything goes seamlessly.