Welcome to the Sheraton Clayton Plaza Hotel St. Louis.  We are just minutes from St. Louis' best entertainment options, including the History Museum, Art Museum and St. Louis Zoo.  In addition, we are conveniently situated in the midst of several corporate headquarters and collegiate areas including Brown Shoe, Build-A-Bear, Enterprise Rent-A-Car, Panera Bread, Centene Corporation, Spartech Corporation, Furniture Brand, Washington University, St. Louis University and Fontbonne.

Newly redesigned from top to bottom, Sheraton Clayton Plaza Hotel St. Louis infuses a contemporary look and comfortable feel into it’s 18,000 square feet of modern, flexible function space that can accommodate a wide variety of groups.  From the intimate business setting of our executive boardroom to the variety of our three ballrooms and various sized breakout rooms, Sheraton has the perfect space for your next Clayton event.